Cell loss in the brain relates to variations in individual symptoms in Huntington’s disease

Huntington’s disease

Cell loss in the brain relates to variations in individual symptoms in Huntington’s disease.

Scientists have wrestled to understand why Huntington’s disease, which is caused by a single gene mutation, can produce such variable symptoms. An authoritative review by a group of leading experts summarizes the progress relating cell loss in the striatum and cerebral cortex to symptom profile in Huntington’s disease, suggesting a possible direction for developing targeted therapies.