Human Brain Project: What is it and how it’s a research innovation

 

Assembly of The Human Brain Project has a goal to unravel what lies within the intricately woven network that still remains a secret. Humans are always interested in discovering the unknown, solving puzzles and riddles and unraveling century-old questions. We have gone deep underwater in search for ancient civilizations and explored time-worn ruins from top to bottom in order to find the answers we so desperately seek. To this day, however, the biggest mystery that we have found is ourselves and what makes us human. The central core of the enigma that we are facing is the brain. The brain is the most puzzling, peculiar and unexplained creation that we have come so far managed to come across. Continue reading to find out more about the human brain project. 

The Human Brain Project

The Human Brain Project
by NeilConway 

What Is The Human Brain Project?

The Human Brain Project is a research initiative that started in 2013 and will continue for ten years. It hopes to uncover the challenge that is understanding the brain and all its functions, pathways and networks. The Human Brain Project will do so by combining and compiling the efforts from the leading scientists from the three major disciplines. By using the three disciplines it will attempt to encompass all that is the brain. It aims for a collaboration and integration between the fields of medicine related to the brain, neuroscience, and computing. This collaboration within the variety of different specialties is set to develop new insights into various neurological disorders and diseases. The initiative plans to come up with new solutions for treatment and to manufacture novel ingenious technologies. The researchers will use these new developments to study the brain.

The Human Brain Project: Neuroscience, Medicine, and Computing

The Human Brain Project

The Human Brain Project
by Fotografia cnj

Medicine and biomedical research initiative will look into neurological diseases and research into earlier diagnosis and prevention of the diseases. They will try to create individualized treatment and therapeutic techniques. All of this will allow for a faster and more efficient manufacturing of drugs. This will potentially lead to making drug discovery more cost-efficient.

Various neuroimaging techniques that scientists use in neuroscience are able to come with a vast pool of experimental data. Further research will use this data for future progress with the knowledge of the network. Both, invasive and non-invasive tools that differ in spatial and temporal resolutions attempt to provide a fuller picture of the brain both, anatomically and functionally. These tools include electroencephalography (EEG), intracranial EEG, functional magnetic resonance imaging (fMRI), transcranial magnetic stimulation (TMS) etc.

Researchers will then process and analyze all of the neuroimaging obtained data. They will then be able to draw clear and concise conclusions that are statistically significant and relevant for further research. That’s where computing can come in with the variety of different programming languages. Programming languages will help guide the analysis of the data in a step-by-step way in an approachable fashion.

Computing also works in order to develop new ways of brain imaging and stimulation. It optimizes the ones that are already available on the market. It will also create computational and theoretical models that explain various time and spatial events in the brain. Computer specialists are also looking into possibilities of creating artificial intelligence programs. Intelligent programs could be able to mimic the functions of the brain.

The Human Brain Project – Goals and Objectives

Implementing clear and concise goals will help guarantee success. Collaboration between medicine, neuroscience, and computing will help to accomplish that. The Human Brain Project aims to create advanced information communication technologies that are able to lift the curtain to not only comprehend the human brain but to be able to stimulate it. This stimulation needs to be as painless, easy and side effect free, as possible.

Main Objectives

  1. Create and design a way to arrange, synthesize and analyze experimental brain data and learn to develop models based on this data. Comprehend both human and nonhuman brains at every level. Start from the genetic components and move on to cognitive makeup and resulting in conscious and unconscious behavior.
  2. Analyze the experimental data via the use of created technologies. Understand the mathematical and psychophysical assumptions and criteria that govern the connections amid various levels of brain organization. Try to understand the functions that these connections play in the brain’s ability to gather, express and collect information. Develop a technology that is able to visualize this data. Allow for creation of online models and reciprocate simulation.
  3. Develop information communication technologies that are useful for researchers in the field of biomedicine, computing, and neuroscience. Provide a platform for creating new technologies associated with artificial intelligence that is useful for understanding and stimulating the brain.
  4. Create new example bioinformatics tools. Immediately use them for pharmacological research and diagnostic criteria for various neurological diseases, online simulations of the disease action. Progress with understanding the newly created tools. Learn about protein on protein docking and interactions and subsequent drug effects to different brain disorders.

Models for brain research

The Human Brain Project

The Human Brain Project
by :+:Mis ViP:+:

Mice models

These objectives also contain mini-objectives for specific goals and guidelines for research projects and future collaborations. Neuroscience will look at projects in regarding with building a multi-layered model of the mouse brain structure. Various up-to-date scientific studies showed that mice models are some of the most useful models to apply to the rest of the mammal population, including humans.

Due to this, it is important to look at the structure and functional capabilities of mice in order to see how certain neurological diseases are able to develop and progress in their brain. This can help with knowing how certain drugs and protein interactions will work in combination with the disease. Drug interactions will then help to speculate and make an accurate prediction of how the disease will work in the human brain.

Creating a mice model will allow a prototype for the future study of the human brain and a guideline for further research. Using various tools can help with progress, including non-invasive and invasive neuroimaging techniques and in vitro and in vivo studies with neuronal mice cells.

Human models

Scientists also have to create a similar multi-layered model of the human brain. They will have to pool the information from the experimental data that they had gathered. Apart from that scientists will need to use the data they are working with at the moment. In the end, the researchers will be able to create a holistic model of the whole human brain. Again, they can do so by using various methods for this particular goal.

Apart from creating the model of the human brain, researchers have to look into understanding the link between the anatomical structures and the various functions that the brain displays. They need to start measuring spiking activities (action potentials) and relationships between different neurons. This will help with searching for some specific neurons with very specific functions (e.g. the grandmother cells) or networks of neurons responsible for similar functions.

Theoretical and computational tools

Researchers can then use various theoretical and computational models in order to hypothesize and speculate about the actions of these neurons. We need to be able to know exactly what happens on the neuronal level. That will allow us to understand the internal cognition and the external behavior that can happen as a result of this spiking activity.

In order to gain this insight into the brain scientists will implement these objectives. They will include the collaborative and ongoing use of all of the techniques available on-hand and feedback and forward communication between the various disciplines. Surprisingly enough, this mirrors the feedback and the feedforward way the brain sends and receives inputs and signals.

Human Brain Project Obstacles

Various different organizations have voiced questions regarding the ambitious initiative that is the Human Brain Project. These questions are valid on a scientific level, as well as a more cultural and an ethical level. Considering them is important before continuing along with the project.

Questions that were raised include ethical considerations.

  • Why do we need to know more about the brain?
  • If we do find out, what will we do with the knowledge that we have will gain?
  • Would there be any repercussions for the knowledge in regards to how we live on a daily basis?
  • Is intervening and stimulating such an important organ ethically reasonable and how would that affect our consciousness and cognition?

Obstacles like this need to be considered in every experiment and study that becomes a part of the whole Human Brain Project.

Human Brain Project Criticisms

There have been many concerns regarding the Human Brain Project. The attempt to model and build a simulation of the entire brain is quite ambitious. Sometimes, however, it is not as doable as one might hope. The amount of money spent on the project is very large and there is still no real advancement with building that holistic brain picture. A thorough experiment needs to be well thought out and planned out and the Human Brain Project seems to pursue a grand idea but with no clear steps to success.

In order for it to work, the brain simulation needs to working as soon as possible so that scientists can test it and make sure that it works, however, there is no such thing on the horizon just yet. If the researchers spend all the money now and then find out the errors, it can become quite catastrophic. Apart from that, how do you describe a brain? There are many different parts of the brain. It seems a bit too ambitious to encompass all that is the brain in one single model including the neurons and protein, DNA makes up etc. It’s impossible to know where the researchers should start.

We have a huge pool of data but it’s all so vast and different from one another, it can be virtually impossible to put it all together into one single brain simulation. Before we do that we need to formulate a theory and a hypothesis about how we think it works and builds from there, and not just throw all the data available to us in a computer and hope for the best. The thought of that, however, is mind-boggling and exciting.

The Impact of The Human Brain Project

Breakthroughs in neuroscience and medicine come as a result of the ongoing research. Different research groups look into different problems regarding the brain. Even with all of the ongoing research, there is still so much to learn and so little that we do know.

The questions are grand and they branch out in many different ways. Some scientists look at how babies are able to learn and speak their native language. Others connect language learning to bilingualism and its possible role in neurological diseases like dementia. Researchers look into reward systems and decision making. They try fully understanding object recognition, feature integration and biased competition of the visual neurons. The scope of the information that they need to study is endless and all of that encompasses The Human Brain Project.

The Human Brain Project Collaborative Initiative

With the advancements in all three of the fields, including research and advanced technology development, it will become possible to understand cognitive processes, advanced behavior, critical thinking, and reasoning. It will be easier to understand the genetic and environmental factors playing into the development and progression of various neurological diseases. Knowing about the diseases will help learn more about the cognitive consequences that show up as symptoms. After that, it will become possible to develop new treatment strategies in the form of drugs and therapy.

The Human Brain Project is, therefore, very ambitious. If it manages to succeed, it can become one of the greatest collaborative initiative in the world that can help us fully understand our species.

References

Markram, H. (2011). Introducing the Human Brain Project. SciVerse ScienceDirect (pp. 39-42). Lausanne: Procedia Computer Science.

Markram, H. (2012). The Human Brain Project – Preparatory Study. Lausanne: The HpB-PS Consortium.

 

Valerie is a psychology student who is trying to pursue a career in Cognitive Neuroscience. She is passionate about the brain and finds it fascinating. She loves learning about new discoveries and research that is going on in the world of psychology and neuroscience. One day she hopes to contribute to the scientific community!